pI: 6.8505 |
Length (AA): 156 |
MW (Da): 18148 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 108 | 3dpl (R) | 19 | 108 | 78.00 | 0 | 1 | 1.33492 | 0.85 |
23 | 104 | 4p5o (B) | 23 | 104 | 96.00 | 0 | 1 | 1.41704 | 0.68 |
50 | 101 | 1iym (A) | 128 | 179 | 31.00 | 0 | 0.63 | 0.623333 | 0.17 |
75 | 104 | 5din (A) | 46 | 75 | 33.00 | 0.051 | 0.53 | 0.628708 | -0.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127986)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G42830 | RING-box protein 1 |
Arabidopsis thaliana | AT5G20570 | RING-box protein 1 |
Babesia bovis | BBOV_III007590 | hypothetical protein |
Brugia malayi | Bm1_05985 | hyperosmotic protein 21 |
Caenorhabditis elegans | CELE_ZK287.5 | Protein RBX-1 |
Cryptosporidium hominis | Chro.80112 | ring-box 1; RING box protein 1; regulator of cullins 1; RING finger protein; ZYP protein |
Cryptosporidium parvum | cgd8_930 | RBX1 ortholog, RING finger |
Dictyostelium discoideum | DDB_G0287629 | hypothetical protein |
Drosophila melanogaster | Dmel_CG16988 | CG16988 gene product from transcript CG16988-RA |
Drosophila melanogaster | Dmel_CG16982 | CG16982 gene product from transcript CG16982-RC |
Echinococcus granulosus | EgrG_001017200 | RING box protein pip1 |
Echinococcus granulosus | EgrG_000673500 | RING box protein |
Entamoeba histolytica | EHI_151630 | RING finger protein, putative |
Echinococcus multilocularis | EmuJ_001017200 | RING box protein pip1 |
Echinococcus multilocularis | EmuJ_000673500 | RING box protein |
Giardia lamblia | GL50803_8241 | HRT1-like protein |
Homo sapiens | 9978 | ring-box 1, E3 ubiquitin protein ligase |
Leishmania braziliensis | LbrM.21.0040 | ring-box protein 1, putative |
Leishmania donovani | LdBPK_210040.1 | ring-box protein 1, putative |
Leishmania infantum | LinJ.21.0040 | ring-box protein 1, putative |
Leishmania major | LmjF.21.0023 | ring-box protein 1, putative |
Leishmania mexicana | LmxM.21.0023 | ring-box protein 1, putative |
Loa Loa (eye worm) | LOAG_03239 | ring-box protein 1 |
Mus musculus | 100043674 | predicted gene 9840 |
Mus musculus | ENSMUSG00000022400 | ring-box 1 |
Neospora caninum | NCLIV_013420 | Anaphase-promoting complex subunit 11, related |
Oryza sativa | 4326152 | Os01g0106800 |
Plasmodium berghei | PBANKA_0806200 | E3 ubiquitin-protein ligase RBX1, putative |
Plasmodium falciparum | PF3D7_0319100 | E3 ubiquitin-protein ligase RBX1, putative |
Plasmodium knowlesi | PKNH_0822400 | E3 ubiquitin-protein ligase RBX1, putative |
Plasmodium vivax | PVX_095280 | E3 ubiquitin-protein ligase RBX1, putative |
Plasmodium yoelii | PY00969 | putative ring finger protein |
Saccharomyces cerevisiae | YOL133W | SCF ubiquitin ligase complex subunit HRT1 |
Schistosoma japonicum | Sjp_0207670 | ko:K03868 RING-box protein 1, putative |
Schmidtea mediterranea | mk4.000758.00 | RING-box protein 1 |
Trypanosoma brucei gambiense | Tbg972.10.2190 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.1810 | RING-H2 zinc finger, putative |
Trypanosoma congolense | TcIL3000_10_1530 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.506495.9 | RING-H2 zinc finger, putative |
Trypanosoma cruzi | TcCLB.503965.20 | RING-H2 zinc finger, putative |
Toxoplasma gondii | TGME49_213690 | ring box protein 1 family protein |
Theileria parva | TP04_0669 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_399840 | RING finger, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1810 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1810 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1810 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1810 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK287.5 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_ZK287.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_ZK287.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK287.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK287.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_ZK287.5 | Caenorhabditis elegans | sterile | wormbase |
YOL133W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0806200 | Plasmodium berghei | Essential | plasmo |
TGME49_213690 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.